Total ankle replacement (TAR) is a surgical procedure performed to relieve pain and restore motion in patients with severe ankle arthritis. While it provides excellent outcomes in most cases, one of the most serious complications is infection, known as periprosthetic joint infection (PJI). These infections can be difficult to manage due to the ankle’s limited soft-tissue coverage and relatively poor blood flow. Recognizing early symptoms, identifying risk factors, and understanding treatment options are essential for successful outcomes.
Functional Anatomy
The ankle joint is formed by the tibia, fibula, and talus, stabilized by surrounding ligaments and tendons. It is designed to allow dorsiflexion and plantarflexion as well as slight rotation, providing both stability and flexibility. Because of its compact anatomy and thin soft-tissue envelope, the ankle is particularly vulnerable to infection and wound healing complications following surgery.
Biomechanics or Physiology
The ankle endures significant stress during walking and weightbearing, with forces up to five times body weight transmitted through the joint. TAR prostheses must replicate the ankle’s natural movement while maintaining stability under these forces. Infection disrupts normal biomechanics by damaging soft tissues, loosening components, and altering the load distribution between the metal and bone interfaces, leading to pain and loss of function.
Common Variants and Anomalies
Infection rates after TAR are generally reported between 2% and 8.5%. They are classified based on timing and origin: acute postoperative infections (within three months after surgery), chronic infections (developing months to years later, often due to bacterial biofilm formation), and acute hematogenous infections (caused by bacteria spreading through the bloodstream). Chronic infections are more common and often harder to treat.
Clinical Relevance
TAR infections pose a major threat to both limb preservation and joint function. Delayed or inadequate treatment can lead to implant failure, chronic pain, and amputation. Early recognition and timely management are essential to salvage the prosthesis and prevent permanent disability. Understanding risk factors and preventive strategies is crucial for orthopedic surgeons, as well as for patients undergoing joint replacement.
Imaging Overview
Radiographic evaluation plays a key role in diagnosing TAR infections. X-rays can reveal loosening of the implant or bone erosion. CT and MRI are useful for assessing bone loss, abscess formation, or sinus tracts, while ultrasound can identify fluid collections and guide aspiration for microbiological testing. Blood tests (ESR, CRP) and joint aspiration are used to confirm infection and identify the bacteria involved.
Associated Conditions
Certain medical conditions and lifestyle factors increase the risk of infection after TAR, including diabetes, peripheral vascular disease, obesity, smoking, rheumatoid arthritis, immunosuppression, and a history of ankle trauma or prior surgery. These conditions reduce tissue perfusion and healing capacity, making infection control more difficult.
Surgical or Diagnostic Applications
Treatment depends on the infection’s timing and severity. Early infections may be treated with debridement, antibiotics, and implant retention (DAIR). Chronic or recurrent infections often require a two-stage revision procedure, where the implant is removed, the joint is cleaned, and an antibiotic spacer is inserted until infection control is achieved, followed by reimplantation. If infection persists or soft tissues are compromised, ankle fusion (arthrodesis) or amputation may be necessary.
Prevention and Maintenance
Preventing TAR infections begins before surgery through patient optimization and careful surgical planning. Key measures include administering prophylactic antibiotics, controlling blood sugar in diabetic patients, encouraging smoking cessation, and ensuring meticulous surgical technique and sterile field maintenance. Postoperatively, proper wound care, regular follow-up, and early detection of complications are essential to reduce infection risk.
Research Spotlight
A recent study systematically reviewed 71 reports on total ankle replacement (TAR) infections, analyzing 10,662 ankle implants and 298 cases of periprosthetic joint infection (PJI). The average infection rate was 3.8%, though rates ranged widely from 0.2% to 26%.
Most infections developed late—months or even years after surgery—and were challenging to treat due to the ankle’s limited soft-tissue coverage and blood flow. The most common bacteria identified were Staphylococcus aureus and coagulase-negative Staphylococci. Surgical management strategies varied, but two-stage revision (removal of the implant, infection control, and later reimplantation) was the most common, though its success rate was lower than for hip or knee replacements.
Single-stage revisions and irrigation with implant retention (DAIR) had higher failure rates, often leading to eventual ankle fusion or, rarely, amputation. The authors emphasized that while TAR infection is uncommon, it is one of the most devastating complications, and more consistent, multicenter research is needed to improve treatment outcomes. (“Study on infection outcomes after total ankle replacement – see PubMed.“)
Summary and Key Takeaways
Total ankle replacement offers motion-preserving pain relief for severe ankle arthritis but carries a small risk of infection, typically 2–8.5%. Early infections may be managed with debridement and antibiotics, while chronic infections often require implant removal or fusion. Risk factors such as diabetes, vascular disease, and smoking significantly increase infection risk. Prevention—through meticulous surgical technique, patient optimization, and vigilant postoperative care—is the best strategy. Successful outcomes depend on early detection and a multidisciplinary approach involving orthopedic surgeons and infectious disease specialists.
References / Citations (Optional)
Myerson MS, Shariff R, Zonno AJ. “The Management of Infection Following Total Ankle Replacement: Demographics and Treatment.” Orthobullets.
Do you have more questions?
How are infections diagnosed after total ankle replacement surgery?
Infections after total ankle replacement surgery are diagnosed through a combination of clinical assessment, laboratory tests (such as blood tests and joint fluid analysis), and imaging studies (such as X-rays and MRI scans).
What are the risk factors for developing an infection after total ankle replacement surgery?
Risk factors for developing an infection after total ankle replacement surgery include diabetes, obesity, smoking, immunosuppression, previous joint infections, and poor wound healing.
How are infections treated after total ankle replacement surgery?
Infections after total ankle replacement surgery are typically treated with a combination of antibiotics, surgical debridement (cleaning out infected tissue), and, in severe cases, revision surgery to remove and replace the infected components.
Can infections after total ankle replacement surgery lead to complications or implant failure?
Yes, infections after total ankle replacement surgery can lead to complications such as chronic pain, joint instability, bone loss, and implant failure, necessitating additional surgeries and potentially compromising long-term outcomes.
What are the different types of infections that can occur after total ankle replacement surgery?
Different types of infections that can occur after total ankle replacement surgery include superficial skin infections, deep soft tissue infections, and deep joint infections (also known as periprosthetic joint infections or PJIs).
How soon after surgery can infections occur, and what is the typical timeline for their onset?
Infections after total ankle replacement surgery can occur at any time, but they most commonly present within the first few weeks to months after surgery. However, delayed-onset infections can also occur months to years later.
Are there any preventive measures that can reduce the risk of infections after total ankle replacement surgery?
Yes, several preventive measures can reduce the risk of infections after total ankle replacement surgery, including preoperative screening and optimization of medical conditions, perioperative antibiotics, meticulous surgical technique, and postoperative wound care.
How effective are antibiotics in preventing infections after total ankle replacement surgery?
Prophylactic antibiotics given before and/or during surgery are effective in reducing the risk of infections after total ankle replacement surgery, but proper selection, timing, and duration of antibiotic therapy are crucial to prevent complications such as antibiotic resistance.
What is the role of wound care in preventing infections after total ankle replacement surgery?
Proper wound care, including keeping the incision clean and dry, changing dressings as instructed, and monitoring for signs of infection, is essential in preventing infections after total ankle replacement surgery.
Are there any specific precautions or restrictions patients should follow to reduce the risk of infections after total ankle replacement surgery?
Patients should follow their surgeon’s instructions regarding postoperative care, including avoiding submerging the incision in water, refraining from smoking, and adhering to prescribed activity modifications to minimize the risk of infections.
How are infections classified and graded in the context of total ankle replacement surgery?
Infections after total ankle replacement surgery are classified and graded based on various factors such as the timing of onset, microbial pathogens involved, severity of symptoms, and extent of tissue involvement.
Can infections after total ankle replacement surgery spread to other parts of the body or lead to systemic complications?
Yes, infections after total ankle replacement surgery can spread to surrounding tissues, nearby joints, or the bloodstream, causing systemic complications such as sepsis, osteomyelitis, or septic arthritis if not promptly diagnosed and treated.
How do surgeons determine the appropriate treatment approach for infections after total ankle replacement surgery?
Surgeons determine the appropriate treatment approach for infections after total ankle replacement surgery based on factors such as the type and severity of infection, the patient’s overall health, the presence of implant loosening or instability, and the likelihood of achieving successful eradication.
Are there any specific imaging modalities used to diagnose infections after total ankle replacement surgery?
Yes, imaging modalities such as X-rays, CT scans, MRI scans, and nuclear medicine studies (such as bone scans or leukocyte imaging) may be used to diagnose infections after total ankle replacement surgery and assess the extent of soft tissue and bone involvement.
What is the role of joint aspiration or arthrocentesis in diagnosing infections after total ankle replacement surgery?
Joint aspiration or arthrocentesis involves obtaining a sample of joint fluid from the affected ankle to analyze for signs of infection, such as elevated white blood cell count, presence of bacteria, or inflammatory markers, aiding in the diagnosis and management of infections.
Can infections after total ankle replacement surgery be treated with non-surgical methods alone?
Infections after total ankle replacement surgery often require a combination of non-surgical methods (such as antibiotics and close monitoring) and surgical interventions (such as debridement or revision surgery) to effectively eradicate the infection and preserve joint function.
What are the chances of recurrence or reinfection after successfully treating an infection following total ankle replacement surgery?
The chances of recurrence or reinfection after successfully treating an infection following total ankle replacement surgery depend on various factors such as the underlying cause, adequacy of treatment, patient compliance, and ongoing surveillance for complications.
How does the presence of medical comorbidities, such as diabetes or immunosuppression, affect the management and outcomes of infections after total ankle replacement surgery?
Medical comorbidities such as diabetes or immunosuppression can complicate the management and outcomes of infections after total ankle replacement surgery by impairing wound healing, increasing the risk of complications, and compromising the body’s ability to fight infections.
Can infections after total ankle replacement surgery be prevented through the use of antibiotic-coated implants or other advanced techniques?
Antibiotic-coated implants and other advanced techniques such as intraoperative bacterial detection systems or biofilm-targeting therapies show promise in reducing the risk of infections after total ankle replacement surgery, but further research is needed to evaluate their long-term efficacy and safety.
How do surgeons balance the need for aggressive treatment of infections after total ankle replacement surgery with the goal of preserving joint function and minimizing morbidity?
Surgeons balance the need for aggressive treatment of infections after total ankle replacement surgery with the goal of preserving joint function and minimizing morbidity by individualizing treatment plans based on patient-specific factors, infection characteristics, and expected outcomes.
